Learning lessons from the Ringaskiddy incineration story

The inclusion of incineration in waste management policies has proven very contentious in the Republic of Ireland. Even though the Cork Region Waste Management Strategy (1995-2020) acknowledged the role of incineration it came as no surprise that a planning application in May 2001 by Indaver Ireland for two incinerators in Cork Harbour was met with fierce local opposition. This paper tells the story which unfolded from May 2001 to May 2007 and examines the roles played by public bodies such as Cork County Council, An Bord Pleanála, the Environmental Protection Agency and the Health and Safety Authority. The Indaver case reveals flaws in the planning process and highlights the need for a more coordinated approach which fosters trust, credibility and legitimacy

Structural Design Optimisation Using Genetic Algorithms and Neural Networks

This paper relates to the optimisation of structural design using Genetic Algorithms (GAs) and presents an improved method for determining the fitness of genetic codes that represent possible design solutions. Two significant problems that often hinder design optimisation using genetic algorithms are expensive fitness evaluation and high epistasis. Expensive fitness evaluation results in slow evolution and occurs when it is computationally expensive to test the effectiveness of possible design solutions using an objective function. High epistasis occurs when certain genes lose their significance or value when other genes change. Consequently, when a fit genetic code has an important gene changed this can have a dramatic effect on the fitness of that genetic code. Often the reduction in fitness results in failure of the genetic code being selected for reproduction and inclusion in the next generation. This loss of evolved genetic information can result in the solution taking considerable time to discover

The transformation of Ireland 1958 - 93: the role of ideas in punctuating institutional path dependency at critical junctures

Ireland experienced two critical junctures when its economic survival was threatened: 1958/9 and 1986/7. Common to both crises was the supplanting of long established practices, that had become an integral part of the political culture of the state, by new ideas that ensured eventual economic recovery. In their adoption and implementation these ideas also fundamentally changed the institutions of state – how politics was done, how it was organised and regulated. The end result was the transformation of the Irish state. The main hypothesis of this thesis is that at those critical junctures the political and administrative elites who enabled economic recovery were not just making pragmatic decisions, their actions were influenced by ideas. Systematic content analysis of the published works of the main ideational actors, together with primary interviews with those actors still alive, reveals how their ideas were formed, what influenced them, and how they set about implementing their ideas. As the hypothesis assumes institutional change over time historical institutionalism serves as the theoretical framework. Central to this theory is the idea that choices made when a policy is being initiated or an institution formed will have a continuing influence long into the future. Institutions of state become ‘path dependent’ and impervious to change – the forces of inertia take over. That path dependency is broken at critical junctures. At those moments ideas play a major role as they offer a set of ready-made solutions. Historical institutionalism serves as a robust framework for proving that in the transformation of Ireland the role of ideas in punctuating institutional path dependency at critical junctures was central

A call for preventing suicide by hanging from ceiling fans: An interdisciplinary research agenda

Hanging is a common method of suicide in several countries. Even as global suicide rates decrease, there is no evidence of suicides by hanging declining. There is limited research by type of hanging, and only a few papers present suicide by hanging from ceiling fans. Our paper proposes a research agenda that will: specify the size of the problem of hanging by ceiling fan (Stage 1: Surveillance), use standard engineering product development processes to modify ceiling fans for reducing their lethal capacity (Stage 2: Design Testing and Redevelopment), and examine the resulting beta-and release-build fans for safety and potential to reduce suicide in community samples (Stage 3: Evaluation)

Catalytic mechanism and pH dependence of a methyltransferase ribozyme (MTR1) from computational enzymology

A methyltransferase ribozyme (MTR1) was selected in vitro to catalyze alkyl transfer from exogenous O6-methylguanine (O6mG) to a target adenine N1, and recently, high-resolution crystal structures have become available. We use a combination of classical molecular dynamics, ab initio quantum mechanical/molecular mechanical (QM/MM) and alchemical free energy (AFE) simulations to elucidate the atomic-level solution mechanism of MTR1. Simulations identify an active reactant state involving protonation of C10 that hydrogen bonds with O6mG:N1. The deduced mechanism involves a stepwise mechanism with two transition states corresponding to proton transfer from C10:N3 to O6mG:N1 and rate-controlling methyl transfer (19.4  kcal·mol-1 barrier). AFE simulations predict the pKa for C10 to be 6.3, close to the experimental apparent pKa of 6.2, further implicating it as a critical general acid. The intrinsic rate derived from QM/MM simulations, together with pKa calculations, enables us to predict an activity-pH profile that agrees well with experiment. The insights gained provide further support for a putative RNA world and establish new design principles for RNA-based biochemical tools.</p

Oscillation frequencies and mode lifetimes in alpha Centauri A

We analyse our recently-published velocity measurements of alpha Cen A (Butler et al. 2004). After adjusting the weights on a night-by-night basis in order to optimize the window function to minimize sidelobes, we extract 42 oscillation frequencies with l=0 to 3 and measure the large and small frequency separations. We give fitted relations to these frequencies that can be compared with theoretical models and conclude that the observed scatter about these fits is due to the finite lifetimes of the oscillation modes. We estimate the mode lifetimes to be 1-2 d, substantially shorter than in the Sun.Comment: Accepted by Ap